300 billion CFUs/gram
Ingredients: Bifidobacterium Breve
Why High Potency? How much should I take?
Using a dose less than 25 Billion per day will have limited health benefits -- you will need a higher potency to get desirable results. Many people have used other probiotic brands with minimal results because of their low potency.
It depends on the person and the issue that is being addressed. You’ll start to see results at a minimum of 25 Billion CFUs per day. The average daily dose by our customers is between 200-400 Billion CFUs per day. Some people see significant results with dosages as high as 800 Billion CFUs per day.
How much should I take?
It depends on the person and the issue that is being addressed. You’ll start to see results at a minimum of 25 Billion CFUs per day. The average daily dose by our customers is between 200-400 Billion CFUs per day. Some people see significant results with dosages as high as 800 Billion CFUs per day. Using a dose less than 25 Billion per day will have limited health benefits -- you will need a higher potency to get desirable results. Many people have used other probiotic brands with minimal results because of their low potency.
10g Size ($2.98 per gram):
600 servings if using 5 Billion CFU serving size (~1/256 teaspoon or 15.625mg)
300 servings if using 10 Billion CFU serving size (~1/128 teaspoon or 31.25mg)
150 servings if using 20 Billion CFU serving size (~1/64 teaspoon or 62.5mg)
75 servings if using 40 Billion CFU serving size (~1/32 teaspoon or 125mg)
40 servings if using 75 Billion CFU serving size (1/16 teaspoon or 0.25g)
20 servings if using 150 Billion CFU serving size (1/8 teaspoon or 0.5g)
50g Size ($2.40 per gram)
3,200 servings if using 5 Billion CFU serving size (~1/256 teaspoon or 15.625mg)
1,600 servings if using 10 Billion CFU serving size (~1/128 teaspoon or 31.25mg)
800 servings if using 20 Billion CFU serving size (~1/64 teaspoon or 62.5mg)
~400 servings if using 40 Billion CFU serving size (~1/32 teaspoon or 125mg)
200 servings if using 75 Billion CFU serving size (1/16 teaspoon or 0.25g)
100 servings if using 150 Billion CFU serving size (1/8 teaspoon or 0.5g)
50 servings if using 300 Billion CFU serving size (1/4 teaspoon or 1g)
100g Size ($1.96 per gram):
6,400 servings if using 5 Billion CFU serving size (~1/256 teaspoon or 15.625mg)
3,200 servings if using 10 Billion CFU serving size (~1/128 teaspoon or 31.25mg)
1,600 servings if using 20 Billion CFU serving size (~1/64 teaspoon or 62.5mg)
800 servings if using 40 Billion CFU serving size (~1/32 teaspoon or 125mg)
400 servings if using 75 Billion CFU serving size (1/16 teaspoon or 0.25g)
200 servings if using 150 Billion CFU serving size (1/8 teaspoon or 0.5g)
100 servings if using 300 Billion CFU serving size (1/4 teaspoon or 1g)
Statement on Allergens
Free of Artificial Colors or Flavors
How long will a 50 gram or 100 gram powder last?
50 grams will last about 2 months if you take 200 Billion CFUs per day or 8 months if you take 50 Billion CFUs per day. 100 grams will last about 4 months if you take 200 Billion CFUs per day.
Can infants and children take probiotics?
Based on existing research, infants can start taking probiotics at 6 months of age.
How much probiotics can an infant take?
Infants can take up to 50 Billion CFU per day.
What are CFUs?
CFU stands for Colony Forming Unit. This is the bacterial count of probiotics.
Why aren’t BulkProbiotics enteric coated?
Enteric coated probiotics are mainly a marketing gimmick. The strains that are used at BulkProbiotics are vetted to have excellent acid and bile tolerance as well as the capacity to survive intestinal transit.
What happens if I leave the probiotics outside of the refrigerator for a couple of days?
2 year temperature stability testing has been performed on our probiotics and the loss would be negligible. Our probiotics can remain at room temperature (or travel) for 2-3 weeks with limited loss, however, it is best to store the probiotics in the refrigerator for optimum potency.
Why do some individuals get a “die-off” reaction?
This is due to a ‘war’ that occurs between the probiotics and the bad bacteria in your body. If there is a large imbalance in your gut bacteria, the die-off reaction will be higher. To avoid this we recommend that you gradually increase your dosage starting with about 25 Billion CFU per day and increase every few days over a couple of weeks.
Do your probiotics contain any dairy or gluten?
Our probiotics are dairy and gluten free. They do not utilize milk, milk derivatives, GOS, or Inulin as additional ingredients in the fermentation media.
When should I take probiotics? Is it ok to take probiotics with drugs, vitamins, or antibiotics?
As a digestive aid, it is best to take 30 minutes before a meal; otherwise, it is also ok to take on an empty stomach in the morning or at bedtime (at least 2 hours after eating). Probiotics should not be taken with antibiotics (take 2 hours before or after taking antibiotics).
What is the return policy?
We accept returns within 30 days for all 10g probiotic powders that are unopened. We do not accept returns for any other sizes. The 10g size is available to experiment to help you find the right probiotic strains for you.
- breve is a promising probiotic that has suppressed allergies, gastrointestinal infections, and inflammation in children. Other research suggests that it could improve skin health in adults. Could you benefit? Learn more here.
What is Bifidobacterium breve?
Bifidobacterium breve is a beneficial bacterium that can be found in human breast milk and the gastrointestinal tracts of infant and adult humans. As an individual ages, the total population of B. breve within their gut decreases .
Possibly Effective For
1) Skin Health
- breve and galactooligosaccharides (GOS) increased skin hydration and clearness in two studies of a total of 141 healthy young adult and adult women [2, 3].
- breve also prevented water loss, improved skin elasticity and hydration, and attenuated the damage induced by chronic UV irradiation (photoaging) in mice [4, 5, 6].
- breve reduced the risk of developing eczema and atopic sensitization in 117 infants at high risk of allergic disease .
Administration of B. breve to 19 preterm infants triggered an anti-inflammatory response that may be of benefit in attenuating allergic reactions .
- breve improved symptoms of allergic hypersensitivity to cow’s milk and atopic dermatitis in 17 infants and 15 children [9, 10].
Oral administration of B. breve shortly after birth can significantly alleviate the symptoms of allergic rhinitis in newborn mice .
- breve mediates anti-inflammatory and anti-allergic reactions in newborn rats .
Oral administration of B. breve suppresses the Th2 immune response and IgE production and modulates the systemic Th1/Th2 balance in allergic mice .
3) Gut Health
Gut Microbiota in Infants
In a study of 30 low birth weight infants with no other deformities, chromosomal abnormalities, or intrauterine infections, early administration of B. breve promoted the colonization of Bifidobacteria and the formation of normal intestinal flora .
- breve also significantly decreased aspirated air volume and improved weight gain in 10 very low birth weight infants .
- breve inhibits coliforms in laboratory settings, suggesting that it could outcompete harmful gut flora .
Constipation and Diarrhea
Bifidobacterium breve together with Streptococcus thermophilus reduced the severity of acute diarrhea and dehydration among 971 healthy young infants .
Bifidobacterium breve is effective in diminishing abdominal pain and increasing stool frequency in 20 children with functional constipation .
Bifidobacterium breve reduced the incidence, severity, and duration of diarrhea in rats with rotavirus infection .
- breve significantly lowered fat mass and improved γ-glutamyltranspeptidase and high-sensitivity C-reactive protein in 52 adults with a tendency for obesity .
- breve reduced body weight gain and accumulation of visceral fat in a dose-dependent manner, and improved serum levels of total cholesterol, fasting glucose and insulin in a mouse model of diet-induced obesity .
- breve modified gene expression of pathways involved in lipid metabolism, response to stress and insulin sensitivity in multiple mouse studies [22, 21].
Soy germ isoflavones fermented by B. breve lowered triglyceride (TG) levels and suppressed the absorption of excessive lipids and fat cell differentiation in rats .
5) Necrotizing Enterocolitis
- breve was associated with decreased risk of necrotizing enterocolitis in 1755 neonates .
Oral administration of B. breve reduced the production of butyric acid in 66 infants, which may be helpful in protecting low birth weight infants from digestive diseases such as necrotizing enterocolitis .
However, one study found no benefit in B. breve administration for the prevention of necrotizing enterocolitis and late-onset sepsis in 1315 very preterm infants .
- breve suppresses inflammation, reduced the pathology and increases survival in rats with necrotizing enterocolitis .
- breve suppressed inflammation in weaning rats with colitis .
- breve significantly attenuated the severity of colitis  and inflammatory cytokine expression in mice [30, 31].
6) Celiac Disease
- breve decreases the production of the pro-inflammatory cytokine TNF-α in 49 children with Celiac disease on a gluten-free diet .
- breve significantly inhibited rotavirus multiplication and prevented rotavirus infection in 10 infants .
Oral administration of B. breve enhances antigen-specific IgA antibody against rotavirus and prevents rotavirus-induced diarrhea in mouse pups .
- breve enhances the antiviral immune response . Mice fed Bifidobacterium breve and immunized orally with influenza virus were more strongly protected against influenza virus infection .
- breve showed promising probiotic properties and beneficial immunomodulatory activity in blood cells taken from volunteers with allergic asthma .
- breve had strong anti-inflammatory properties in asthmatic mice .
- breve combined with fructooligosaccharides prevented allergic airway inflammation in mice .
- breve with non-digestible oligosaccharides suppressed pulmonary airway inflammation, T cell activation, and mast cell degranulation in mice with asthma .
- breve increased total BDNF total in rats .
10) Cigarette Smoke Associated Pulmonary Diseases
Based on anti-inflammatory effects in human blood cells activated by cigarette smoke, B. breve is being investigated for its potential to help cigarette smoke-associated diseases such as Chronic obstructive pulmonary disease (COPD) .
Mechanism of Effect
Researchers have investigated the mechanism of the effect of B. breve in cell and animal studies. In these, B. breve has:
- Limited excessive Th1 and Th2 responses .
- Reduced Th1  and Th17  and increases Th2  and Treg .
- Decreased IgE [11, 13] and IgG1  in allergies.
- Increased IgA  and IgG  in infection.
- Increased TGF-β1 .
- Decreased TNF-α [32, 44] [a study where it is increased: 46].
- Decreased IL-1β, IL-23 , IL-4 [13, 41], IL-6 [41, 44] and increased IL-8 , IL-21  and IL-27 .
- Decreased  or increased  IFN-γ.
- Increased IL-10 [45, 13, 40, 42, 47, 46] [studies where IL-10 was reduced: 41, 44].
- Increased FOXP3 [40, 42] and CD4+CD25+Foxp3+Treg cells .
- Decreased LPL, GPX2, LBP , CXCL8 [30, 44] and HMGB1 .
- Increased RANTES .
- Suppressed NF-κB activation .
*These statements have not been evaluated by the Food and Drug Administration.
*These products are not intended to diagnose, treat, cure, or prevent any disease.