500 billion CFUs/gram
Ingredients: Bifidobacterium Lactis
Why High Potency? How much should I take?
Using a dose less than 25 Billion per day will have limited health benefits -- you will need a higher potency to get desirable results. Many people have used other probiotic brands with minimal results because of their low potency.
It depends on the person and the issue that is being addressed. You’ll start to see results at a minimum of 25 Billion CFUs per day. The average daily dose by our customers is between 200-400 Billion CFUs per day. Some people see significant results with dosages as high as 800 Billion CFUs per day.
How much should I take?
It depends on the person and the issue that is being addressed. You’ll start to see results at a minimum of 25 Billion CFUs per day. The average daily dose by our customers is between 200-400 Billion CFUs per day. Some people see significant results with dosages as high as 800 Billion CFUs per day. Using a dose less than 25 Billion per day will have limited health benefits -- you will need a higher potency to get desirable results. Many people have used other probiotic brands with minimal results because of their low potency.
10g Size ($2.98 per gram):
1,000 servings if using 5 Billion CFU serving size (~1/256 teaspoon or 15.625mg)
500 servings if using 10 Billion CFU serving size (~1/128 teaspoon or 31.25mg)
250 servings if using 20 Billion CFU serving size (~1/64 teaspoon or 62.5mg)
100 servings if using 50 Billion CFU serving size (~1/32 teaspoon or 125mg)
40 servings if using 125 Billion CFU serving size (1/16 teaspoon or 0.25g)
20 servings if using 250 Billion CFU serving size (1/8 teaspoon or 0.5g)
50g Size ($2.76 per gram)
5,000 servings if using 5 Billion CFU serving size (~1/256 teaspoon or 15.625mg)
2,500 servings if using 10 Billion CFU serving size (~1/128 teaspoon or 31.25mg)
1,250 servings if using 20 Billion CFU serving size (~1/64 teaspoon or 62.5mg)
500 servings if using 50 Billion CFU serving size (~1/32 teaspoon or 125mg)
200 servings if using 125 Billion CFU serving size (1/16 teaspoon or 0.25g)
100 servings if using 250 Billion CFU serving size (1/8 teaspoon or 0.5g)
50 servings if using 500 Billion CFU serving size (1/4 teaspoon or 1g)
100g Size ($2.31 per gram):
10,000 servings if using 5 Billion CFU serving size (~1/256 teaspoon or 15.625mg)
5,000 servings if using 10 Billion CFU serving size (~1/128 teaspoon or 31.25mg)
2,500 servings if using 20 Billion CFU serving size (~1/64 teaspoon or 62.5mg)
1,000 servings if using 50 Billion CFU serving size (~1/32 teaspoon or 125mg)
400 servings if using 125 Billion CFU serving size (1/16 teaspoon or 0.25g)
200 servings if using 250 Billion CFU serving size (1/8 teaspoon or 0.5g)
100 servings if using 500 Billion CFU serving size (1/4 teaspoon or 1g)
Statement on Allergens
Free of Artificial Colors or Flavors
How long will a 50 gram or 100 gram powder last?
50 grams will last about 2 months if you take 200 Billion CFUs per day or 8 months if you take 50 Billion CFUs per day. 100 grams will last about 4 months if you take 200 Billion CFUs per day.
Can infants and children take probiotics?
Based on existing research, infants can start taking probiotics at 6 months of age.
How much probiotics can an infant take?
Infants can take up to 50 Billion CFU per day.
What are CFUs?
CFU stands for Colony Forming Unit. This is the bacterial count of probiotics.
Why aren’t BulkProbiotics enteric coated?
Enteric coated probiotics are mainly a marketing gimmick. The strains that are used at BulkProbiotics are vetted to have excellent acid and bile tolerance as well as the capacity to survive intestinal transit.
What happens if I leave the probiotics outside of the refrigerator for a couple of days?
2 year temperature stability testing has been performed on our probiotics and the loss would be negligible. Our probiotics can remain at room temperature (or travel) for 2-3 weeks with limited loss, however, it is best to store the probiotics in the refrigerator for optimum potency.
Why do some individuals get a “die-off” reaction?
This is due to a ‘war’ that occurs between the probiotics and the bad bacteria in your body. If there is a large imbalance in your gut bacteria, the die-off reaction will be higher. To avoid this we recommend that you gradually increase your dosage starting with about 25 Billion CFU per day and increase every few days over a couple of weeks.
Do your probiotics contain any dairy or gluten?
Our probiotics are dairy and gluten free. They do not utilize milk, milk derivatives, GOS, or Inulin as additional ingredients in the fermentation media.
When should I take probiotics? Is it ok to take probiotics with drugs, vitamins, or antibiotics?
As a digestive aid, it is best to take 30 minutes before a meal; otherwise, it is also ok to take on an empty stomach in the morning or at bedtime (at least 2 hours after eating). Probiotics should not be taken with antibiotics (take 2 hours before or after taking antibiotics).
What is the return policy?
We accept returns within 30 days for all 10g probiotic powders that are unopened. We do not accept returns for any other sizes. The 10g size is available to experiment to help you find the right probiotic strains for you.
- lactis is an important component of the healthy gut flora. It may promote GI well-being, especially in children, and some evidence suggests it may help the body prevent and fight off infections.
What is Bifidobacterium lactis?
Bifidobacterium lactis is a gram-positive rod-shaped bacterium which can be found in the gut of most mammals, including humans. It is considered to be part of the healthy, beneficial gut flora .
Possibly Effective For
1) Gut Health
Diarrhea and Constipation
- lactis milk formula administered to 50 children with acute diarrhea decreased the frequency, duration of diarrhea, and hospital stay .
- animalis spp. lactis prevented acute diarrhea in 90 infants .
Treatment with B. animalis spp. lactis and inulin shortened the duration of acute diarrhea in 156 children. The benefits were most pronounced in cases of Rotavirus diarrhea .
- animalis spp. lactis together with Streptococcus thermophilus reduced the frequency of antibiotic-associated diarrhea (AAD) in 80 infants .
Ingestion of fresh cheese enriched with B. animalis spp. lactis showed beneficial effects on constipation symptoms in women .
Fermented milk containing B. animalis spp. lactis had beneficial effects on stool frequency, defecation condition and stool consistency in 135 adult women with constipation .
- animalis ssp. lactis increased Bifidobacteria and improved constipation in 17 human subjects .
- animalis had a beneficial effect on discomfort, bloating and constipation in 274 constipation-predominant IBS patients .
B animalis spp. lactis significantly improved objectively measured abdominal girth and gastrointestinal transit, as well as reduced symptomatology in 34 IBS patients .
- animalis spp. lactis and inulin significantly reduced treatment side effects and indirectly increased eradication rates by increasing patient compliance in 47 patients with symptomatic H. pylori infection .
- animalis spp. lactis supplementation can increase Bifidobacteria and reduce Enterobacteriaceae and Clostridium in 324 infants .
4 weeks’ supplementation with B. animalis ssp. lactis resulted in a clinically relevant benefit on defecation frequency in 1248 healthy adults with abdominal discomfort .
Probiotic fermented milk containing B. animalis spp. lactis by healthy women may improve GI well-being and decrease the frequency of GI symptoms [17, 18, 19].
Gut Benefits in Animals
- animalis ssp. lactis protected against NSAID-induced GI side effects in rats and may prevent more serious GI mucosal damage and/or enhance the recovery rate of the stomach mucosa .
- animalis ssp. lactis improved colitis in mice [21, 22, 23].
- animalis spp. lactis exhibited anti-inflammatory effects and reduces the incidence of diarrhea in rats with colitis .
- animalis ssp. lactis protected barrier functions by restoring intestinal permeability, colonic goblet cell populations, and cytokine levels. It also restores the Th1/Th2 ratio by increasing the Th2 response in mice with chronic low-grade intestinal inflammation .
- animalis ssp. lactis reduced days with cold/flu in 30 young healthy adults .
109 infants and children receiving B. animalis ssp. lactis experienced fewer respiratory tract infections [27, 28].
This probiotic did not, however, have an effect on the prevention of gastrointestinal and respiratory tract infections in daycare centers  and hospitalized children .
- animalis ssp. lactis protected mice and rats from Toxoplasma gondii [31, 32] and nematode parasite infections .
- animalis ssp. lactis protected mice against Salmonella infection and reduced infection severity [34, 35].
- animalis ssp. lactis reduced the severity of infection due to E. coli in mice .
3) Infant Growth
- animalis spp. lactis supplementation had a positive effect on growth in 594 vulnerable infants, such as infants born to mothers with HIV , and preterm infants .
Daily ingestion of milk containing B. animalis ssp. lactis significantly reduced the BMI, total cholesterol, low-density lipoprotein, and inflammatory markers in a study of 51 human patients with metabolic syndrome .
In the same study, B. animalis ssp. lactis significantly reduced BMI, total cholesterol, low-density lipoprotein and inflammatory cytokines .
The presence of B. animalis was also found to be negatively associated with BMI in two studies of a total of 378 human volunteers [41, 42].
- animalis ssp. lactis reduced weight gain, fat mass and improved glucose tolerance in obese mice .
- animalis ssp. lactis improved glycemia and reduced insulin levels in obese rats .
5) Anemia in Children
Milk with B. animalis ssp. lactis and prebiotic oligosaccharides reduced the risk of being anemic and iron deficient by 45% and increased weight gain by 0.13 kg/year in 624 children from 1-4 years of age .
- animalis ssp. lactis augmented immunity in 26 healthy young women .
- animalis spp. lactis supplementation in pregnancy influenced fetal immune parameters as well as immunomodulatory factors in breast milk in 71 women .
In a study of 172 otherwise healthy infants, B. animalis ssp. lactis mitigated the negative immune-related effects of not breastfeeding and cesarean delivery, possibly by augmenting the immune response, evidenced by increased anti-rotavirus- and anti-poliovirus-specific IgA .
- animalis ssp. lactis stimulated the immune response to vaccination in 211 healthy adults .
- animalis ssp. lactis significantly improved eczema symptoms in 27 infants .
- animalis ssp. lactis improved immune parameters, decreased Th2 cytokines, and improved nasal symptoms in adult subjects suffering from seasonal allergic rhinitis .
B animalis skewed the Th1/Th2 balance towards Th1 in mice with allergies .
- animalis ssp. lactis added to yogurt post-fermentation had anti-inflammatory properties in 30 healthy adults .
- animalis ssp. lactis inhibited inflammation in elderly volunteers .
- animalis ssp. lactis reduced inflammatory and T cells mediators, promoted regulatory T cells specific markers, reduced weight loss, and attenuated epithelial damage in mice with colitis .
- animalis spp. lactis beneficially modified gut microbiota in 20 elderly volunteers, by increasing Bifidobacteria, Lactobacilli, and Enterococci and reducing Enterobacteria .
- animalis spp. lactis enhanced natural immunity in 25 healthy elderly subjects .
- animalis spp. lactis increased leukocyte phagocytic in the elderly. Increases in the proportions of total, helper (CD4(+)), and activated (CD25(+)) T lymphocytes and natural killer cells were also observed [58, 59, 60].
- animalis ssp. lactis reduced weight gain and fat mass and improves glucose tolerance in diabetic mice .
- animalis ssp. lactis decreased fasting insulin and blood glucose and significantly improved insulin tolerance in mice with noninsulin-dependent diabetes mellitus. This probiotic also improved diabetes-induced total cholesterol and triglyceride (TG) levels and increased the muscle glycogen content .
11) Antioxidant Activity
- animalis culture supernatant, intact cells, and intracellular cell-free extracts all effectively scavenged free radicals and significantly enhanced the activities of antioxidative enzymes in mice .
12) Celiac Disease
Live B. animalis ssp. lactis bacteria directly counteracted the harmful effects exerted by celiac-toxic gluten (or, rather, a component of gluten called gliadin) on human intestinal cells .
13) Autoimmune Disease
In rats with experimental autoimmune encephalomyelitis, B. animalis significantly reduced the duration of clinical symptoms .
- animalis ssp. lactis possesses the OXC gene, encoding oxalyl-coenzyme A (CoA) decarboxylase, a key enzyme in oxalate degradation .
- animalis ssp. lactis significantly decreased urinary oxalate excretion in mice with hyperoxaluria by degrading dietary oxalate thus limiting its absorption across the intestine .
Mechanism of Effect
Researchers have been investigating the mechanisms by which B. animalis exerts its effects in animals and cells. In their findings, this probiotic has:
- Increased IgA [35, 47, 48, 36, 46], IgG, IgG1, and IgG3 .
- Elevated NK-cell cytotoxicity .
- Decreased TNF-α [40, 24, 54].
- Increased TGF-β1 .
- Increased IFN-α  and IFN-γ .
- Increased IL-2  and IL-10 [35, 25].
- Increased IL-4 and IL-5 in low-grade inflammation .
- Decreased IL-5 and IL-13 in allergy .
- Both decreased  and increased  IL-6.
- Decreased iNOS, COX-2 , PCK1 and G6PC .
- Increased PP-1, GLUT4  and FOXP3 .
- Induced CD19 lymphocyte proliferation in parasite infection .
- Mostly decreased NF-κB [69, 23] [a study where it was increased: 68].
*These statements have not been evaluated by the Food and Drug Administration.
*These products are not intended to diagnose, treat, cure, or prevent any disease.