200 billion CFUs/gram
Ingredients: L. Brevis
Why High Potency? How much should I take?
Using a dose less than 25 Billion per day will have limited health benefits -- you will need a higher potency to get desirable results. Many people have used other probiotic brands with minimal results because of their low potency.
It depends on the person and the issue that is being addressed. You’ll start to see results at a minimum of 25 Billion CFUs per day. The average daily dose by our customers is between 200-400 Billion CFUs per day. Some people see significant results with dosages as high as 800 Billion CFUs per day.
10g Size ($2.98 per gram):
666 servings if using 3 Billion CFU serving size (~1/256 teaspoon or 15.625mg)
400 servings if using 5 Billion CFU serving size (~1/128 teaspoon or 31.25mg)
200 servings if using 10 Billion CFU serving size (~1/64 teaspoon or 62.5mg)
100 servings if using 20 Billion CFU serving size (~1/32 teaspoon or 125mg)
40 servings if using 50 Billion CFU serving size (1/16 teaspoon or 0.25g)
20 servings if using 100 Billion CFU serving size (1/8 teaspoon or 0.5g)
50g Size ($2.14 per gram)
3,333 servings if using 3 Billion CFU serving size (~1/256 teaspoon or 15.625mg)
2,000 servings if using 5 Billion CFU serving size (~1/128 teaspoon or 31.25mg)
1,000 servings if using 10 Billion CFU serving size (~1/64 teaspoon or 62.5mg)
500 servings if using 20 Billion CFU serving size (~1/32 teaspoon or 125mg)
200 servings if using 50 Billion CFU serving size (1/16 teaspoon or 0.25g)
100 servings if using 100 Billion CFU serving size (1/8 teaspoon or 0.5g)
50 servings if using 200 Billion CFU serving size (1/4 teaspoon or 1g)
100g Size ($1.78 per gram):
6,666 servings if using 3 Billion CFU serving size (~1/256 teaspoon or 15.625mg)
4,000 servings if using 5 Billion CFU serving size (~1/128 teaspoon or 31.25mg)
2,000 servings if using 10 Billion CFU serving size (~1/64 teaspoon or 62.5mg)
1,000 servings if using 20 Billion CFU serving size (~1/32 teaspoon or 125mg)
400 servings if using 50 Billion CFU serving size (1/16 teaspoon or 0.25g)
200 servings if using 100 Billion CFU serving size (1/8 teaspoon or 0.5g)
100 servings if using 200 Billion CFU serving size (1/4 teaspoon or 1g)
Statement on Allergens
Free of Artificial Colors or Flavors
How long will a 50 gram or 100 gram powder last?
50 grams will last about 2 months if you take 200 Billion CFUs per day or 8 months if you take 50 Billion CFUs per day. 100 grams will last about 4 months if you take 200 Billion CFUs per day.
Can infants and children take probiotics?
Based on existing research, infants can start taking probiotics at 6 months of age.
How much probiotics can an infant take?
Infants can take up to 50 Billion CFU per day.
What are CFUs?
CFU stands for Colony Forming Unit. This is the bacterial count of probiotics.
Why aren’t BulkProbiotics enteric coated?
Enteric coated probiotics are mainly a marketing gimmick. The strains that are used at BulkProbiotics are vetted to have excellent acid and bile tolerance as well as the capacity to survive intestinal transit.
What happens if I leave the probiotics outside of the refrigerator for a couple of days?
2 year temperature stability testing has been performed on our probiotics and the loss would be negligible. Our probiotics can remain at room temperature (or travel) for 2-3 weeks with limited loss, however, it is best to store the probiotics in the refrigerator for optimum potency.
Why do some individuals get a “die-off” reaction?
This is due to a ‘war’ that occurs between the probiotics and the bad bacteria in your body. If there is a large imbalance in your gut bacteria, the die-off reaction will be higher. To avoid this we recommend that you gradually increase your dosage starting with about 25 Billion CFU per day and increase every few days over a couple of weeks.
Do your probiotics contain any dairy or gluten?
Our probiotics are dairy and gluten free. They do not utilize milk, milk derivatives, GOS, or Inulin as additional ingredients in the fermentation media.
When should I take probiotics? Is it ok to take probiotics with drugs, vitamins, or antibiotics?
As a digestive aid, it is best to take 30 minutes before a meal; otherwise, it is also ok to take on an empty stomach in the morning or at bedtime (at least 2 hours after eating). Probiotics should not be taken with antibiotics (take 2 hours before or after taking antibiotics).
What is the return policy?
We accept returns within 30 days for all 10g probiotic powders that are unopened. We do not accept returns for any other sizes. The 10g size is available to experiment to help you find the right probiotic strains for you.
The probiotic L. brevis has many potential benefits to dental health, immunity, and the gut, while new research suggests it could also help with sleep and inflammation.
What is Lactobacillus brevis?
Lactobacillus brevis is a plant-derived lactic acid bacterium isolated from ‘Suguki’, a traditional Japanese pickle produced in Kyoto .
- brevis can be found in fermented foods such as sauerkraut and pickles. It is also a normal part of the human gut microbiota.
Possibly Effective For
- brevis reduced the incidence of influenza in 1089 elementary school children. The improvement was especially pronounced in unvaccinated individuals .
Oral administration of live, but not heat-killed, L. brevis significantly increased IFN-α production in 60 volunteers. The intake tended to be most beneficial in subjects with initially low levels of IFN-α production .
- brevis alleviated influenza virus infection symptoms in mice .
- brevis enhanced cytotoxic activity of mouse splenocytes .
- brevis exhibited antiviral activity towards herpes virus (HSV-2) and inhibits HSV-2 multiplication .
2) Dental Health
- brevis improved oral pH, reduced salivary Streptococcus mutans, and reduced bleeding on probing in 191 high caries risk schoolchildren .
- brevis had anti-inflammatory effects and brought about the total disappearance or amelioration of clinical symptoms in 8 healthy subjects and 21 patients with periodontitis .
- brevis exerted oral anti-inflammatory properties, possibly by preventing nitric oxide synthesis, in 34 healthy adults .
- brevis inhibited periodontal inflammation, significantly decreased bone loss and lowered the count of anaerobic bacteria in mice with periodontitis .
3) Gut Health
Heat-killed L. brevis improved intestinal function in 32 women with constipation and promoted the growth of Bifidobacteria .
Marked enhancement of NK-cell activity and improved bowel symptoms were observed in 44 female students with constipation, who consumed pickles containing dead L. brevis cells .
- brevis improved quality of life, reduced diarrhea and abdominal pain, and increased Bifidobacteria in patients with IBS .
- brevis treatment decreased H. pylori colonization and reduced polyamine biosynthesis in dyspeptic 22 H. pylori patients .
Heat-killed L. brevis reduced intestinal impairments and improved survival rate in mice with lethal colitis .
Polyphosphate (polyP), an active molecule derived from L. brevis, improved inflammation and fibrosis in mice with chronic colitis .
Insufficient Evidence For
The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of L. brevis probiotics for any of the below-listed uses. Remember to speak with a doctor before taking L. brevis probiotics, and never use them in place of something your doctor recommends or prescribes.
In 17 volunteers with insomnia, L. brevis showed a mildly beneficial effect on sleep .
Daily voluntary wheel-running and sleep rhythmicity become intensified in mice when heat-killed L. brevis is added to the diet .
5) Oral Mucositis
Oral mucositis is one of the most common, debilitating complications of cance treatments, particularly chemotherapy and radiation. In 200 patients, L. brevis reduced the incidence and severity of anticance therapy-induced oral mucositis and improved the tolerance to chemo-radiotherapy, and anticance treatment completion .
Capsules containing L. brevis reduced monosodium glutamate (MGS) levels and MSG symptom complex in 30 humans .
- brevis inhibited the absorption of MSG from the intestine into the blood in mice .
Animal & Cell Research
No clinical evidence supports the use of L. brevis probiotics for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.
- brevis induced Th1 cytokines, inhibited Th2 cytokines, reduced anti-allergen antibodies and suppressed systemic anaphylaxis in mice .
- brevis inhibited IgE production and histamine secretion in allergic mice by shifting the Th1/Th2 balance toward Th1 dominance .
Oral administration of L. brevis significantly inhibited IgE production, swelling, and the development of atopic dermatitis in mice .
- brevis reduced cholesterol in rats and decreased low-density lipoprotein (LDL) cholesterol levels .
9) Fat Metabolism
In a cell study, L. brevis inhibited fat cell production, cellular triglyceride accumulation, and GPDH activity .
- brevis enhanced appetite in mice .
- brevis decreased glucose levels in diabetic rats .
- brevis supplementation was associated with increased insulin levels in healthy rats .
12) Liver Function
Oral administration of L. brevis ameliorated ethanol-induced liver injury and the fatty liver in mice. It significantly inhibited ALT and AST increase, and decreased TG and total cholesterol in the liver .
13) Skin Health
- brevis increased blood flow and decreases transepidermal water loss in rats, suggesting that it could be a useful substance in skin health, specifically chapped or dry skin. This has not been investigated in humans .
Organophosphorus hydrolase (OpdB) of L. brevis is able to degrade organophosphorus pesticides .
Mechanism of Effect
In cells and animals, researchers have observed that L. brevis:
- Shifted the Th1/Th2 balance toward Th1 dominance .
- Polarized M1 macrophages to M2-like macrophages .
- Increased IgA  and inhibited IgE .
- Beneficially affected various physiological processes via the serotonin 5-HT3 receptor [34, 31].
- Decreased TNF-α [27, 15, 17, 16, 14, 30, 9].
- Increased IFN- α [2, 3], and both increased  and decreased IFN-γ .
- Decreased IL-1β [15, 17, 16, 14, 9], IL-4 , IL-6 [27, 15, 16, 9], and IL-17A .
- Increased IL-10 [16, 25].
- Both decreased  and increased IL-12 .
- Both decreased  and increased TGF-β .
- Increased adiponectin .
- Decreased iNOS[15, 16], NO, PGE2 , COX2 [15, 16], MPO, FOXP3, TLR4 , PGE2, MMP , PPAR-γ, CEBP-α, aP2, LPL, LXR– α, leptin, GPDH , IRAK1, AKT, NF-κB , SREBP-1, and SREBP-2 .
- Increased HSPs and p38 MAPK .
- brevis is considered safe for human consumption .
- brevis can produce biogenic amines like tyramine and putrescine [36, 37].
Probiotics should be avoided in patients with organ failure, immunocompromised status, and dysfunctional gut barrier mechanisms, where they may cause infections. To avoid any adverse effects or unexpected interactions, talk to your doctor before taking L. brevis probiotics.
*These statements have not been evaluated by the Food and Drug Administration.
*These products are not intended to diagnose, treat, cure, or prevent any disease.