L. Gasseri 300 billion CFUs/gram (Refrigerated, Live Probiotic, No Fillers)
Ingredients: Lactobacillus Gasseri (L. Gasseri)
FOR ORAL USE ONLY (taken by mouth).
Histamine Free
NOTE: This is live bacteria and must be kept in the refrigerator.
We do not ship with an ice pack. The probiotics are freeze dried so they will withstand warm temperatures during your shipment.
DO NOT purchase no filler probiotic powder if it is NOT refrigerated. Fillers like maltodextrin, silicon dioxide, magnesium stearate, etc keep probiotics alive outside of the refrigerator (these fillers also cause a lot of digestive problems so we don't use them). The CFU count will be much lower than advertised for no filler powders that are not refrigerated.
We keep all our powders in the refrigerator before shipment. It will maintain potency for 5 weeks outside of the refrigerator so it will be ok when shipped to you.
FREE US SHIPPING.
*Free international shipping over $100 USD (use code FREESHIPPING at checkout).
How do I measure this?
Two measuring spoons are included. The small spoon is 30 Billion CFU (0.1g) and the big spoon is 240 Billion CFU (0.8g).
Why powder and not capsules?
Our probiotic powder has no additives. Many people don't realize that a lot of additives worsen their symptoms. Additionally, the microbiome in your mouth, esophagus, and stomach are incredibly important to your health. Taking our flavorless probiotic powder keeps those areas healthy.
Why High Potency? How much should I take?
Using a dose less than 25 Billion per day will have limited health benefits -- you will need a higher potency to get desirable results. Many people have used other probiotic brands with minimal results because of their low potency.
It depends on the person and the issue that is being addressed. You’ll start to see results at a minimum of 25 Billion CFUs per day. The average daily dose by our customers is between 200-400 Billion CFUs per day. Some people see significant results with dosages as high as 800 Billion CFUs per day.
10g Size ($2.98 per gram):
100 servings if using 30 Billion CFU serving size (~1/32 teaspoon or 125mg)
50g Size ($2.14 per gram)
3,200 servings if using 5 Billion CFU serving size (~1/256 teaspoon or 15.625mg)
1,600 servings if using 10 Billion CFU serving size (~1/128 teaspoon or 31.25mg)
800 servings if using 20 Billion CFU serving size (~1/64 teaspoon or 62.5mg)
~400 servings if using 40 Billion CFU serving size (~1/32 teaspoon or 125mg)
200 servings if using 75 Billion CFU serving size (1/16 teaspoon or 0.25g)
100 servings if using 150 Billion CFU serving size (1/8 teaspoon or 0.5g)
50 servings if using 300 Billion CFU serving size (1/4 teaspoon or 1g)
100g Size ($1.78 per gram):
6,400 servings if using 5 Billion CFU serving size (~1/256 teaspoon or 15.625mg)
3,200 servings if using 10 Billion CFU serving size (~1/128 teaspoon or 31.25mg)
1,600 servings if using 20 Billion CFU serving size (~1/64 teaspoon or 62.5mg)
800 servings if using 40 Billion CFU serving size (~1/32 teaspoon or 125mg)
400 servings if using 75 Billion CFU serving size (1/16 teaspoon or 0.25g)
200 servings if using 150 Billion CFU serving size (1/8 teaspoon or 0.5g)
100 servings if using 300 Billion CFU serving size (1/4 teaspoon or 1g)
Statement on Allergens
Dairy Free
Sugar Free
Gluten Free
Preservative Free
Soy Free
GMO Free
Yeast Free
Casein Free
Free of Artificial Colors or Flavors
Prebiotic Free
How long will a 50 gram or 100 gram powder last?
50 grams will last about 2 months if you take 200 Billion CFUs per day or 8 months if you take 50 Billion CFUs per day. 100 grams will last about 4 months if you take 200 Billion CFUs per day.
Can infants and children take probiotics?
Based on existing research, infants can start taking probiotics at 6 months of age.
How much probiotics can an infant take?
Infants can take up to 50 Billion CFU per day.
What are CFUs?
CFU stands for Colony Forming Unit. This is the bacterial count of probiotics.
Why aren’t BulkProbiotics enteric coated?
Enteric coated probiotics are mainly a marketing gimmick. The strains that are used at BulkProbiotics are vetted to have excellent acid and bile tolerance as well as the capacity to survive intestinal transit.
What happens if I leave the probiotics outside of the refrigerator for a couple of days?
2 year temperature stability testing has been performed on our probiotics and the loss would be negligible. Our probiotics can remain at room temperature (or travel) for 5 weeks with limited loss, however, it is best to store the probiotics in the refrigerator for optimum potency.
Why do some individuals get a “die-off” reaction?
This is due to a ‘war’ that occurs between the probiotics and the bad bacteria in your body. If there is a large imbalance in your gut bacteria, the die-off reaction will be higher. To avoid this we recommend that you gradually increase your dosage starting with about 25 Billion CFU per day and increase every few days over a couple of weeks.
Do your probiotics contain any dairy or gluten?
Our probiotics are dairy and gluten free. They do not utilize milk, milk derivatives, GOS, or Inulin as additional ingredients in the fermentation media.
When should I take probiotics? Is it ok to take probiotics with drugs, vitamins, or antibiotics?
As a digestive aid, it is best to take 30 minutes before a meal; otherwise, it is also ok to take on an empty stomach in the morning or at bedtime (at least 2 hours after eating). Probiotics should not be taken with antibiotics (take 2 hours before or after taking antibiotics).
What is the return policy?
We accept returns within 30 days for all 10g probiotic powders that are unopened. We do not accept returns for any other sizes. The 10g size is available to experiment to help you find the right probiotic strains for you.
L. gasseri is a probiotic that recently gained in popularity due to reports of weight loss and decreased blood sugar. Which of its potential benefits are backed up by science? Read on to find out.
What is Lactobacillus gasseri?
Lactobacillus gasseri is a lactic acid bacteria that is being investigated for various potential health benefits because of its antimicrobial activity, bacteriocin production, and purported modulation of the innate and adaptive immune systems [1].
Potential Benefits of L. gasseri
L. gasseri probiotic supplements have not been approved by the FDA for medical use. Supplements generally lack solid clinical research. Regulations set manufacturing standards for them but don’t guarantee that they’re safe or effective. Speak with your doctor before supplementing.
Possibly Effective For
1) Weight Management
L. gasseri significantly decreased BMI, abdominal visceral fat, waist and hip circumferences, and body fat mass in 210 healthy Japanese adults, with an 8.5% decline in abdominal fat area over twelve weeks. However, the authors warned that constant consumption of this probiotic may be required to maintain this effect [2].
Despite there being no change in behavior or diet, administration of L. gasseri modestly reduced weight and waist and hip circumference in obese and overweight adults [3].
L. gasseri significantly decreased body weight and visceral and subcutaneous fat areas in adults with obese tendencies [4].
L. gasseri reduced body weight and fat tissue mass in mice [5] and rats [6].
L. gasseri prevented weight gain in obese mice [7].
Obesity
L. gasseri prevented abdominal fat accumulation [8] and decreases body weight in adults with obese tendencies [4].
L. gasseri suppressed lipase-mediated fat hydrolysis in humans [8] and mice [9].
L. gasseri prevented the enlargement of fat cells and an increase in abdominal fat volume in rats, mice, and humans [10, 11, 12].
L. gasseri inhibited dietary fat absorption in rats [13].
L. gasseri ameliorated systemic and fat tissue inflammation in obese mice [10], by inhibiting macrophage invasion [7].
Heat-killed L. gasseri stimulated respiratory immune responses of obese host animals to enhance their natural defense against respiratory infection [14].
L. gasseri also significantly reduced leptin concentrations in rats [11, 12, 15].
Insufficient Evidence For
Researchers are currently investigating whether L. gasseri has other health benefits. The potential benefits in this section have produced positive results in at least one clinical trial, but these studies are small, contradictory, or otherwise limited. Talk to your doctor before supplementing with L. gasseri for any reason.
2) Cholesterol
A synbiotic product containing L. gasseri and inulin reduced total blood cholesterol, low-density lipoprotein (LDL)-cholesterol and triglycerides in hypercholesterolemic men and women [16].
L. gasseri significantly reduced the blood and liver cholesterol in rats [12, 17, 18].
3) Immunity
Heat-killed L. gasseri enhanced immunity in the elderly. This probiotic increases the number of CD8(+) T cells and reduces CD28 expression loss in CD8(+) T cells [19].
Heat-killed L. gasseri increased natural killer cell (NK cell) activities and enhanced cell-mediated immunity in aged host animals, thereby altering age-related immunosenescence [20].
Live and heat-killed L. gasseri protected mice against the influenza virus and ameliorated infection symptoms, apparently by stimulating local and systemic immune responses [21, 22].
L. gasseri exhibited anti-herpes virus (HSV-2) activity [23].
4) Gut Health
L. gasseri beneficially modified the microbiota, increasing Bifidobacteria and decreasing Clostridium in human subjects [24].
Heat-killed L. gasseri accelerated the resolution of symptoms and reduced mortality of enteropathogenic E. coli -infected mice [25].
Diarrhea
L. gasseri increased IgA levels in breast milk and reduces the incidence of diarrhea in mouse pups with rotavirus infection [26].
Ulcers
Yogurt containing L. gasseri significantly inhibited the formation of gastric ulcers in rats in a dose-dependent manner [27, 28, 29].
H. pylori
L. gasseri suppressed H. pylori and reduced gastric mucosal inflammation in infected patients [30].
A 4-week treatment with L. gasseri -containing yogurt improved the efficacy of triple therapy in patients with H. pylori infection [31].
L. gasseri yogurt suppressed dyspeptic symptoms in H. pylori-infected patients [32].
L. gasseri significantly reduced the rate of both H. pylori and H. suis infections in mice [33, 34].
5) Allergies
Heat-killed L. gasseri improved nasal symptoms and pollen-specific IgE levels in subjects with Japanese cedar pollinosis [35].
L. gasseri enhanced the Th1 immune responses in subjects with perennial allergic rhinitis [36].
L. gasseri enhanced oral tolerance in allergies in mice, possibly by increasing the ratio of effector regulatory T cells [37].
Heat-killed L. gasseri suppressed eosinophilia in cedar pollen antigen-challenged mice, by modulating the Th1/Th2 balance [38].
6) Fatigue
L. gasseri ingestion prevented the reduction of natural killer (NK) cell activity due to strenuous exercise and elevated mood from a depressed state in university-student athletes [39].
L. gasseri and αLA alleviated minor resting fatigue in university-student athletes after strenuous exercise [39].
7) Endometriosis
L. gasseri improved menstrual pain and dysmenorrhea in patients with endometriosis [40].
L. gasseri inhibited the growth of endometrial tissue in the abdominal cavity in mice and rats [41].
Animal Research (Lacking Evidence)
No clinical evidence supports the use of L. gasseri probiotics for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.
8) Glucose Tolerance
L. gasseri increased energy expenditure, reduced blood glucose, improved glucose tolerance, and attenuated inflammation in rats [42].
It also reduced insulin levels in rats [15].
L, gasseri decreased blood glucose and improves glucose sensitivity in type 2 diabetic mice [43].
9) Metabolic Syndrome
L. gasseri decreased food and energy intakes and improved body weight, insulin resistance, and cholesterol levels in rats with metabolic syndrome (MS) [44].
10) Inflammation
L. gasseri prevented high-fat-diet-induced inflammation and lowered the ratio of inflammatory-type macrophages to anti-inflammatory ones in fat tissue of mice [10].
L. gasseri ameliorated systemic and fat tissue inflammation in obese mice [10, 7].
11) Candida
L. gasseri yogurt prevented proliferative and inflammatory changes in the stomach caused by C. albicans in mucosal candidiasis in rats [45].
12) Asthma
L. gasseri attenuated allergen-induced airway inflammation and IL-17 proinflammatory immune response in mice with allergic asthma [46].
13) Oxalate Degradation
L. gasseri degrades oxalate in laboratory experiments and may be beneficial in managing oxalate kidney stone disease [47].
Mechanism of Effect
Researchers have conducted a number of cell and animal studies to investigate the effect of L. gasseri on a biochemical level. Here are some of their findings:
- Increased IgA in infections [48], increased the IgG2a/IgG1 ratio [38], and decreased IgE in allergies [36].
- Increased TLR2 [48] and BAFF [48].
- Increased TGF-β [48], and TNF-α [49, 22, 25, 44] [a study where TNF-α is decreased: 46].
- Increased IL-1β [25] and IL-2 [22, 20] in infections, but decreased the rate of proliferation and IL-2 production by CD4+ T in allergy [37].
- Mostly increased IL-6 [48, 25, 44] [a study where it is decreased: 46].
- Decreased IL-8 [34] and IL-17A [46].
- Increased IL-10 [48, 49, 37, 25], IL-12 [49, 22, 25, 38], IL-15 and IL-21 [22].
- Increased IFN-γ [22], and IFNAR [20].
- Increased perforin 1 [22].
- Increased intracellular glutathione [49], and GLUT4 [15].
- Decreased CCL2, CCR2, Lep, Nos2 [7], sICAM-1 [10], ACC1, FAS, and SREBP1 [5, 15].
- Increased high-molecular-weight adiponectin [4].
- Increased ACO, CPT1, PPARα, PPARδ [15].
- Increased Mx1 and Oas1a genes, critical for viral clearance [21].
- Decreased CSF2 [38].
- Decreased serum amyloid P component [42].
- Increased PGE2 [29].
- Increased Th1 cells in allergies [36].
- Increased CD8(+) T cells, maintained CD8(+)CD28(+) T cells and lymphocyte transformation [19].
- Inhibited the proliferation of CD4+ T cells and associated inflammatory responses [50].
Safety
Probiotics are generally considered safe. However, the use of probiotics should be avoided in patients with organ failure, immunocompromised status, and dysfunctional gut barrier mechanisms. To prevent adverse side effects, talk to your doctor before starting a new probiotic supplement.
*These statements have not been evaluated by the Food and Drug Administration.
*These products are not intended to diagnose, treat, cure, or prevent any disease.
GMO status
All our probiotic powders do not consist of, nor contain, nor is produced from genetically modified organisms according to the definitions of Regulation (EC) 1829/2003 and Regulation (EC) 1830/2003 of the European Parliament and of the Council of 22 September 2003.