100 billion CFUs/gram
Ingredients: B. Longum
Why High Potency? How much should I take?
Using a dose less than 25 Billion per day will have limited health benefits -- you will need a higher potency to get desirable results. Many people have used other probiotic brands with minimal results because of their low potency.
It depends on the person and the issue that is being addressed. You’ll start to see results at a minimum of 25 Billion CFUs per day. The average daily dose by our customers is between 200-400 Billion CFUs per day. Some people see significant results with dosages as high as 800 Billion CFUs per day.
10g Size ($1.95 per gram):
333 servings if using 3 Billion CFU serving size (~1/128 teaspoon or 31.125mg)
200 servings if using 5 Billion CFU serving size (~1/64 teaspoon or 62.5mg)
100 servings if using 10 Billion CFU serving size (~1/32 teaspoon or 125mg)
50 servings if using 20 Billion CFU serving size (~1/16 teaspoon or 0.25g)
20 servings if using 50 Billion CFU serving size (~1/8 teaspoon or 0.5g)
50g Size ($1.25 per gram)
1,666 servings if using 3 Billion CFU serving size (~1/128 teaspoon or 31.25mg)
~800 servings if using 5 Billion CFU serving size (~1/64 teaspoon or 62.5mg)
~400 servings if using 10 Billion CFU serving size (~1/32 teaspoon or 125mg)
~200 servings if using 20 Billion CFU serving size (1/16 teaspoon or 0.25g)
100 servings if using 50 Billion CFU serving size (1/8 teaspoon or 0.5g)
50 servings if using 100 Billion CFU serving size (1/4 teaspoon or 1g)
100g Size ($1.02 per gram):
3,333 servings if using 3 Billion CFU serving size (~1/128 teaspoon or 31.25mg)
2,000 servings if using 5 Billion CFU serving size (~1/64 teaspoon or 62.5mg)
1,000 servings if using 10 Billion CFU serving size (~1/32 teaspoon or 125mg)
500 servings if using 20 Billion CFU serving size (~1/16 teaspoon or 0.25g)
200 servings if using 50 Billion CFU serving size (1/8 teaspoon or 0.5g)
100 servings if using 100 Billion CFU serving size (1/4 teaspoon or 1g)
Statement on Allergens
Free of Artificial Colors or Flavors
How long will a 50 gram or 100 gram powder last?
50 grams will last about 2 months if you take 200 Billion CFUs per day or 8 months if you take 50 Billion CFUs per day. 100 grams will last about 4 months if you take 200 Billion CFUs per day.
Can infants and children take probiotics?
Based on existing research, infants can start taking probiotics at 6 months of age.
How much probiotics can an infant take?
Infants can take up to 50 Billion CFU per day.
What are CFUs?
CFU stands for Colony Forming Unit. This is the bacterial count of probiotics.
Why aren’t BulkProbiotics enteric coated?
Enteric coated probiotics are mainly a marketing gimmick. The strains that are used at BulkProbiotics are vetted to have excellent acid and bile tolerance as well as the capacity to survive intestinal transit.
What happens if I leave the probiotics outside of the refrigerator for a couple of days?
2 year temperature stability testing has been performed on our probiotics and the loss would be negligible. Our probiotics can remain at room temperature (or travel) for 2-3 weeks with limited loss, however, it is best to store the probiotics in the refrigerator for optimum potency.
Why do some individuals get a “die-off” reaction?
This is due to a ‘war’ that occurs between the probiotics and the bad bacteria in your body. If there is a large imbalance in your gut bacteria, the die-off reaction will be higher. To avoid this we recommend that you gradually increase your dosage starting with about 25 Billion CFU per day and increase every few days over a couple of weeks.
Do your probiotics contain any dairy or gluten?
Our probiotics are dairy and gluten free. They do not utilize milk, milk derivatives, GOS, or Inulin as additional ingredients in the fermentation media.
When should I take probiotics? Is it ok to take probiotics with drugs, vitamins, or antibiotics?
As a digestive aid, it is best to take 30 minutes before a meal; otherwise, it is also ok to take on an empty stomach in the morning or at bedtime (at least 2 hours after eating). Probiotics should not be taken with antibiotics (take 2 hours before or after taking antibiotics).
What is the return policy?
We accept returns within 30 days for all 10g probiotic powders that are unopened. We do not accept returns for any other sizes. The 10g size is available to experiment to help you find the right probiotic strains for you.
The gut microbe B. longum may improve the human immune response and help prevent gut disorders. Early evidence suggests that it may also suppress allergies, reduce cholesterol, and improve skin health. Learn more here.
What is Bifidobacterium longum?
Bifidobacterium longum is a Gram-positive, rod-shaped species of bacteria naturally present in the human GI tract. It’s subspecies B. longum subsp. infantis is one of the earliest bacteria to colonize the infant gut. B. longum is often added to food products as a probiotic with various health benefits.
Previously considered separate species, B. infantis and B. suis were shown to be subspecies of B. longum .
- longum ssp. infantis triggered the anti-poliovirus response in a small study of 20 infants .
- longum ssp. infantis promoted the immune response in human volunteers .
- longum also stimulated immune function in 45 elderly, hospitalized patients who received an influenza vaccine .
- longum ssp. infantis had strong immunomodulatory effect in blood drawn from elderly patients, compared with other well-known commercial strains .
- longum supplementation reduced the incidence of influenza and fever in 27 elderly subjects who received an influenza vaccine .
- longum fed infants showed a trend toward fewer respiratory tract infections .
- longum protected mice against pneumonia-induced death by finely tuning the inflammatory response and speeding up lung recovery .
- longum improved symptoms, reduces mortality and suppresses inflammation in the lower respiratory tract in mice infected with influenza [9, 10].
- longum ssp. infantis inhibited rotavirus infection in mice .
Oral administration of B. longum protects mice against gut-derived sepsis caused by P. aeruginosa .
- longum improves survival in mice infected with Salmonella Typhimurium .
- longum ssp. infantis protects against Salmonella associated injury in mice via a Treg-dependent mechanism [14, 15].
- longum inhibits the growth of C. albicans and other pathogenic bacteria .
2) Celiac Disease
- longum ssp. infantis reduced gastrointestinal symptoms in untreated Celiac disease (CD) patients .
- longum improved gut microbiota composition and immune parameters in children with newly diagnosed CD .
Oral administration of B. longum ameliorated gliadin (gluten)-mediated perturbations in liver iron deposition and mobilization in rats with CD .
- longum attenuated the production of inflammatory cytokines and the CD4+ T-cell mediated immune response and protects newborn rats against gliadin (gluten)-induced enteropathy .
3) Gut Health
Enterotoxigenic Bacteroides fragilis (ETBF) strains have been suggested to be associated with acute and persistent diarrhea, and inflammatory bowel disease. B. longum significantly decreased ETBF in humans .
- longum modulated the intestinal environment and appeared to improve the general health care of elderly patients receiving enteral feeding .
- longum supplementation elevated biotin levels produced by Bacteroides caccae, and increased Eubacterium rectale, a butyrate producer, in mice .
- longum maintained high Lactobacilli levels in mice .
- longum ssp. infantis modulated the gut microbiota and reduces endotoxins in rats .
- longum ssp. infantis increased propionic, succinic acid, and butyric acid in rats .
Administration of B. longum ssp. infantis significantly reduced the incidence of necrotizing enterocolitis (NEC) and associated inflammation in rats .
- longum improved colitis in mice .
- longum ssp. infantis ameliorated colitis in rats  and mice by decreasing Th1 and Th17 responses .
Irritable Bowel Syndrome (IBS)
- longum ssp. infantis reduced intestinal inflammation and was shown to efficiently treat individual and global IBS symptoms without adverse events .
- longum ssp. infantis improved abdominal pain/discomfort, bloating/distention, and bowel movement difficulty in patients with IBS .
- longum ssp. infantis relieved many of the symptoms of IBS in a clinical trial involving women .
- longum ameliorated ulcerative colitis symptoms in Japanese patients .
- longum and B. longum subsp. infantis ameliorated ulcerative colitis in mice [24, 34].
- longum reduced visceral hypersensitivity in mice with IBS .
- longum ssp. infantis significantly reduced visceral pain threshold pressure of the first pain behavior and total number pain behaviors in rats [36, 37].
- longum ssp. infantis reduced proinflammatory markers in patients with ulcerative colitis, chronic fatigue syndrome, and psoriasis .
- longum reduced inflammation and improved symptoms in patients with ulcerative colitis .
- longum significantly alleviated inflammation in mice with gout .
- longum ssp. infantis suppressed proinflammatory IL-17 cytokine production and may be useful in the treatment of Th17-mediated diseases .
Intake of yogurt or powder supplemented with B. longum alleviated subjective symptoms and affected blood markers of allergy in individuals with Japanese cedar pollinosis [42, 43, 44]. Nasal symptoms such as itching, rhinorrhea, and blockage as well as throat symptoms tended to be relieved with this probiotic .
Oral administration of B. longum suppressed IgE levels and improved the IgG2a/IgG1 ratio. It also increased Th1 cytokine and decreased Th2 cytokine production in mice .
- longum balanced the Th1/Th2 response and alleviated β-lactoglobulin allergic inflammation in mice .
Neonatal mother-to-offspring colonization with B. longum reduces allergic responses in mice .
- longum reduced total cholesterol, particularly among subjects with moderate hypercholesterolemia .
- longum supplementation significantly reduced total cholesterol, liver lipid deposition, and adipocyte size and positively affected liver and kidney function in hypercholesterolemic rats .
7) Skin Health
- longum extract, when applied to the skin, was able to improve inflammation parameters, decrease skin sensitivity, increase skin resistance against physical and chemical aggression, and decrease skin dryness in volunteers with sensitive skin .
- longum exerted photoprotective effects on the skin in mice .
8) Liver Health
- longum and fructooligosaccharides (FOS) significantly reduced AST, CRP, HOMA-IR, blood endotoxin and steatosis in patients with non-alcoholic steatohepatitis (NASH) .
- longum and FOS improved biochemical parameters and neuropsychological tests in cirrhotic patients with minimal hepatic encephalopathy (MHE) .
9) Hemodialysis Complications
Oral administration of B. longum decreased serum phosphate levels in 15 patients receiving hemodialysis (HD) .
Animal Research (Lacking Evidence)
No clinical evidence supports the use of B. longum for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.
10) Metabolic Syndrome
- longum improved metabolic parameters in rats on a high-fat diet. This probiotic also reduced metabolic endotoxin concentrations and intestinal inflammation .
11) Cognitive Function
- longum fed mice exhibited improved learning and memory .
- longum normalized anxiety-like behavior and hippocampal brain-derived neurotrophic factor (BDNF) in mice with infectious colitis .
Depression can be reversed in rats by administering B. infantis .
Chronic administration of B. infantis protected rats from depressive symptoms caused by stress induced through maternal separation .
Daily administration of B. longum reduced schizophrenic rearing behavior in mice, decreased the resting level of plasma corticosterone and the ratio of kynurenine to tryptophan .
15) Lung Injury
- longum treatment significantly improved lung injury following infection and sepsis in mice. This probiotic also decreased lung inflammatory responses .
16) Bone Density
- longum supplementation alleviated bone loss and increased bone formation parameters and bone mass density in ovariectomized rats .
Mechanisms of Effect
Various studies have investigated B. longum’s effect on the cellular level. These may or may not reflect the mechanisms of B. longum probiotics in the human body; however, they may help account for some of the observed effects of these probiotics in human studies.
Under inflammatory conditions, B. longum:
- Decreased Th1-related cytokines (T-bet, IL-2, and IFN-γ) and Th17-related cytokines (IL-12p40, RORγt, IL-17A, IL-21, and IL-23), and increases Treg-related molecules (Foxp3, IL-10, and TGF-β) [29, 73, 40, 41, 3, 27].
- Decreased IL-1α , IL-1β [28, 35, 40], IL-6 [74, 38, 27] and IL-18 .
- Decreased TNF-α expression [28, 39, 38, 27].
- Increased IL-27 .
- Decreased CD80 and CD40 , CXCL1 [40, 27], CRP , iNOS and antimicrobial peptides Reg3b and Reg3g .
In infectious conditions, B. longum:
- Increased natural killer (NK) cell activity [4, 6, 9].
- Increased serum IgA  and decreased IgG2a productions .
- Increased IL-2, IL-12, and IL-18 .
- Decreased IL-6 [9, 10] and IL-8 .
- Decreased TNF-α .
- Both increased  and decreased IL-10 , and decreased [10, 13] and increased IFN-γ .
In allergic conditions, B. longum:
- Decreased IgE and improves the IgG2a/IgG1 ratio [48, 50, 75, 75, 76].
- Increased IgA .
- Increased Th1 cytokine and decreased Th2 cytokine production .
- Decreased IL-4 [75, 46] and IL-5  [a case where IL-5 was increased: 46].
- Increased IL-10 , IL-12 [76, 76] and TGF-β .
- Increased [45, 76] or decreased IFN-γ .
- Suppressed MDC and TARC .
- Increased CD4+CD25+Foxp3+ Treg cells .
In celiac disease, B. longum:
- Decreased TNF-α [18, 20].
- Increased NFκB .
- Increased IL-10 .
- Reduced CD3⁺ T , CD4+ and CD4+/Foxp3+ cells  and increased CD8+ T .
- Increased MIP-1β .
- longum is considered safe, but should be avoided in immunocompromised individuals, people with organ failure, and dysfunctional gut barrier, where probiotics may lead to infection. To avoid adverse effects, talk to your doctor about whether probiotics could be appropriate for you.
*These statements have not been evaluated by the Food and Drug Administration.
*These products are not intended to diagnose, treat, cure, or prevent any disease.